Clinical Perspectives™ Highlights from the Perspectives in Melanoma XII Conference

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Continuing Medical Education Information

Target Audience

Dermatologists, surgical oncologists, general surgeons, medical oncologists, and oncology nurses involved in the management of patients with melanoma.

Statement of Need

The Perspectives in Melanoma XII meeting, held in Scheveningen/The Hague, the Netherlands, October 2-4, 2008, was an important forum for discussion of the latest research in many areas of melanoma research. This publication offers a comprehensive overview of the most relevant presentations for those healthcare providers who were unable to attend this noteworthy meeting.

Educational Objectives

Upon proper completion of this CME activity, participants should be able to:

• Better comprehend how insights into melanoma biology/pathogenesis speak to drug resistance and are helping to drive biomarker and treatment development
• Review the importance of the sentinel lymph node both for staging and as a potential focus of attack for regional immunotherapies
• Summarize the current state of adjuvant therapy in melanoma and areas of ongoing research
• Identify alterations in immune function associated with melanoma development or progression, and strategies to improve immune function in melanoma patients
• Evaluate the current state of development of molecularly targeted and other emerging therapies for melanoma

Accreditation and Credit Designation

MelanomaCare, LLC is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. .

MelanomaCare, LLC designates this educational activity for a maximum of 1.5 AMA PRA Category 1 Credit(s)TM.

Each physician should claim only those credits commensurate with the extent of his or her participation in the activity.

Grantor Support

This educational activity is supported by an educational grant from Schering-Plough Corporation.

This educational activity is sponsored by MelanomaCare, LLC, Orangeburg, NY.

Release date:February 15, 2009
Expiration date: February 15, 2010
Estimated time to complete activity: 1.5 hours

Instructions for Participation

To receive a CME certificate of participation, participants should:

• Read the entire publication, including the Continuing Medical Education Information
• Complete the posttest questions and evaluation form on pages 15 and 16 and mail or fax the evaluation form with answer key (page 16) to MelanomaCare, 523 Rt. 303, Orangeburg, NY 10962; Fax: 888-256-5055.
• A certificate of participation will be issued 4 to 6 weeks after receipt of a completed activity evaluation form and a completed posttest with a score of 70% or better.

Faculty Disclosures

In accordance with ACCME requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in this activity.

John M. Kirkwood, MD
Director, Melanoma and Skin Cancer Center
Professor and Vice Chairman for Clinical Research
University of Pittsburgh School of Medicine
Pittsburgh, PA
Grant/Research Support: Berlex, Pfizer Inc, Schering-Plough Corporation
Speakers� Bureau: Schering-Plough Corporation
Retained Consultant: Eleos Inc

Keith T. Flaherty, MD
Assistant Professor of Medicine
University of Pennsylvania
Abramson Cancer Center
Philadelphia, PA
Consultant: Astra Zeneca, Bayer Pharmaceuticals,
Chiron, Genentech, Onyx Pharmaceuticals, Plexxikon, Schering-Plough Corporation

Dirk Schadendorf, MD
Director, Department of Dermatology
University Hospital Essen
Essen, Germany
Grant/Research Support: Schering-Plough Corporation
Speakers� Bureau: Bristol-Myers Squibb, Schering-Plough Corporation
Retained Consultant: Astra Zeneca, Bristol-Myers Squibb, Merck Serono, Schering-Plough Corporation

Resolution of Conflict of Interest

MelanomaCare, LLC has implemented a system to resolve conflicts of interest for each continuing medical education activity to help ensure content objectivity, independence, fair balance, and that the content is aligned with the interest of the public. Conflicts, if any, are resolved through one or more processes, including peer review.