Lorazepam can have anti-anxiety, sedative, antiemetic effects. It helps to relieve muscle spasms through central mechanisms, stops convulsions, improves sleep, eliminates urges to vomit. It has sedative, hypnotic and anxiolytic effect, which is realized at the expense of inhibitory action of gamma-aminobutyric acid in the brain. Seizure syndrome is stopped by the ability to increase the inhibitory processes in the synapses of the cortex, thalamus and limbic system.
Lorazepam is a high-potency benzodiazepine anxiolytic. It was first synthesized and patented in 1963 and marketed in the United States in 1977. The original patent for lorazepam was held by Wyeth, which marketed it in the United States under the trade names Ativan and Temesta. Despite such a venerable age, lorazepam is still one of the most used and prescribed benzodiazepines in the USA and European countries and is included in the World Health Organization's list of most needed medications. In the United States and European countries, lorazepam is also available in injectable form for intravenous and intramuscular administration, as an oral solution and syrup for children, and as patches and gel for application to the skin. However, in the United States, oral forms of lorazepam are not approved in children under 12 years of age (effectiveness and safety in this period are still unknown).
Drug Name: |
Lorazepam (Generic Ativan) |
| Tablet Strength: | 0.5 mg, 1 mg, 2 mg, 2.5 mg |
| Best Price: | $2.52 Per Pill |
Where to Buy Online? |
Visit Pharmacy |
The benzodiazepine anxiolytic Lorazepam is used to treat the following conditions:
During therapy with this drug, patients experience significant relief from anxiety and fear.
Lorazepam therapeutic mechanism of action
Lorazepam differs from all other benzodiazepines in its great therapeutic breadth, its powerful anxiolytic action, and its wide range of other pharmacological effects, even at low doses. They believed that lorazepam was more effective than all other benzodiazepines available on the market at the time, and called it a "new generation benzodiazepine." Evidence is given that lorazepam has atypical effects (both behavioral and physiological) that distinguish it from other benzodiazepines. For example, lorazepam has been shown to have an atypical, relatively benzodiazepine-friendly profile of effects on human cognitive function. It is suggested that the atypical profile of lorazepam may be associated with a preferential effect on those benzodiazepine receptor subtypes that have not yet been sufficiently studied.
Lorazepam in psychiatry
Social phobia
Lorazepam is also effective for sociophobia, including both course treatment and single administration before any stressful social situations for the patient. Lorazepam in the context of sociophobia has been shown to have less cognitive toxicity (i.e., produces fewer cognitive side effects) than the antidepressant often used for potentiation in this context, olanzapine, and than another benzodiazepine with longer duration of action and higher probability of cumulation, clonazepam.
Manic states
Lorazepam in mania not only helps to relieve psychomotor agitation, anxiety, aggression, and dysphoria and normalize sleep, but also a true reduction of manic affect, which allows to reduce doses of antipsychotics and normotics, reduce their side effects and avoid overdose and intoxication. And in mild hypomanic states, lorazepam monotherapy may be sufficient to relieve hypomania. In delirious mania (manic delirium), high doses of lorazepam and electrostimulant therapy are first-line therapy due to the poor tolerance of antipsychotics in this category of patients.
Psychosis
The indirect antidopaminergic effect inherent in benzodiazepines due to their potentiating effect on GABAergic neurotransmission has served as the basis for attempts to use them in psychosis, schizophrenia to potentiate the action of antipsychotics. The use of lorazepam in combination with antipsychotics contributes not only to a more rapid relief of psychomotor agitation, anxiety, insomnia and aggression, but also to strengthening of the true antipsychotic effect and a more rapid reduction of hallucinatory and delusional phenomena.
Acute psychomotor agitation, aggressiveness
Lorazepam can ameliorate acute psychomotor agitation, aggressiveness, and insomnia, contribute to the suppression of nightmares, and normalize the phase structure of sleep regardless of the genesis of agitation, aggressive behavior, and insomnia. However, one meta-analysis has shown no efficacy of benzodiazepines, including lorazepam, in controlling this pathology, either as monotherapy or when used in combination with antipsychotics.
Depressive states
Lorazepam does not appear to have true antidepressant activity. Nevertheless, the combination of lorazepam with an antidepressant often leads to potentiation (enhancement) of the latter, reduction of depressive symptoms, and improvement of antidepressant tolerance (reduction of side effects such as nausea, akathisia, initial agitation, agitation, insomnia during antidepressant therapy) and increased compliance of patients. The addition of lorazepam is particularly effective when the proportion of anxiety, insomnia, agitation or dysphoria in the picture of depression is high, i.e., in anxious, agitated or mixed (dysphoric) depressions.
Lorazepam in neurology
Epilepsy and other seizure syndromes
Lorazepam has strong anticonvulsant activity and can be used to relieve epileptiform seizures of any etiology, including, for example, in status epilepticus. The short-term anticonvulsant effect of lorazepam makes it, along with midazolam, a more convenient means of breaking excessively long convulsions compared to diazepam, since the introduction of lorazepam to break convulsions does not reduce the effectiveness of the session the next day, as occurs when using diazepam.
Alzheimer's disease and other dementias
Benzodiazepines are quite commonly used to relieve agitation, anxiety, aggression, and behavioral disorders in dementia patients. In contrast to antipsychotics, they do not cause metabolic disorders, obesity, worsening of diabetes mellitus, hypertension, or vascular atherosclerosis, nor do they cause motor immobility and increased mortality in elderly patients, although they may cause excessive muscle relaxation and sedation, falls, and femoral neck fractures
Insomniac Disorders
Lorazepam has shown equal efficacy with zopiclone in the treatment of insomniac disorders in patients with acute cerebral circulation disorder or brain injury (the dose of lorazepam in this case was 0.5-1 mg before bedtime for 7 days. Of the short- to medium-acting benzodiazepines, lorazepam and oxazepam are the most commonly prescribed medications for insomnia. This medication is usually prescribed to patients with insomnia against a background of resistant depression, due to the fact that lorazepam minimally lowers the seizure threshold.
Does Lorazepam Deserve a Place in Modern Psychiatry?
Purchasing Ativan (lorazepam) online requires caution, due diligence, and a clear understanding of what distinguishes a legitimate online pharmacy from an illegal or unsafe source. Since Ativan is a Schedule IV controlled substance in the U.S., it is subject to strict federal and state regulations. Buying it online without meeting legal requirements can result in receiving counterfeit medication, facing legal consequences, or risking severe health complications. Here’s a comprehensive step-by-step guide to doing it the right way.
The first and most critical rule is to choose a pharmacy that is licensed and verifiable. In the United States, this means the pharmacy must be certified.
Any online source that offers Ativan without requiring a prescription is unsafe and illegal. These sites often ship counterfeit medications or substitute the drug with potentially harmful substances. Key red flags include:
Legitimate online pharmacies will either:
Many reputable telemedicine platforms offer lorazepam prescriptions after an in-depth online evaluation by a physician licensed in your state. The doctor will assess your symptoms, medical history, and whether Ativan is appropriate for your condition. Only after this process will the medication be dispensed and shipped.
Websites should comply with regional data protection laws. This includes encryption of personal health data, secure checkout systems, and privacy policies clearly stating how your data will be used. Avoid websites that:
While buying online can sometimes save money, prices that are significantly lower than U.S. averages ($2–$10 per tablet for branded Ativan depending on dosage) should raise concern. If prices are too good to be true, they probably are — either the drug is counterfeit, expired, or stolen. Instead, look for sites that offer:
Only standard pharmaceutical dosages of Ativan are available legally in the U.S.: 0.5 mg, 1 mg, and 2 mg. If a site offers unusual doses or bulk powders, it is likely unregulated. Stick to sites that adhere to official pharmaceutical norms.
Reputable pharmacies will ship Ativan from licensed U.S. or regional fulfillment centers. You should receive:
Sites that do not offer shipment tracking or use untraceable courier services should be avoided. Also, make sure the medication is shipped in tamper-proof packaging with patient instructions enclosed.
Before purchasing, review customer feedback on third-party platforms. Legitimate pharmacies will have:
Never purchase Ativan from forums, Reddit threads, Instagram sellers, or general marketplaces like Craigslist or Facebook Marketplace. These sources are unregulated and often linked to counterfeit drug distribution networks.
If a website seems off — inconsistent branding, spelling errors, no clear return/refund policy — don’t risk it. Double-check all credentials and compare them with trusted sources or your local state pharmacy board. You can also contact your physician or pharmacist to cross-check if a particular online pharmacy is reputable.
Buying Ativan online can be done legally and safely, but only if you follow regulated procedures and verify the pharmacy’s legitimacy. Always prioritize physician oversight, prescription validation, and secure fulfillment when choosing an online source for lorazepam.
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